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PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist derived from Melanotan II. Unlike Melanotan II, it does not cause significant pigmentation changes, making it a more selective research tool.
Key Research Areas
- Selective MC3R and MC4R agonist โ studied for CNS-mediated arousal pathways
- Acts centrally via hypothalamic melanocortin receptors
- Studied for both male and female arousal dysfunction models
- Does not cause significant melanogenesis at research doses
- Studied for potential applications in hypoactive sexual desire disorder (HSDD)
Mechanism of Action
PT-141 activates MC3R and MC4R in the hypothalamus and limbic system, triggering dopaminergic and oxytocin pathways associated with arousal and motivation, independent of vascular mechanisms.
๐ฌ โฅ99% by HPLC | Sterile lyophilised powder | Supplied in clear borosilicate glass vial
