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💉 Pre-filled Pen Bundle
MOTS-c
In stock
| Amount | 40mg + Pen |
| Form | Pre-filled Pen Bundle |
| Price | £95.00 |
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2 for £180.50
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3 for £256.50
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5 for £403.75
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MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-derived peptide encoded within the 12S rRNA gene. It acts as a mitochondrial signal to the nucleus, regulating metabolic homeostasis.
Key Research Areas
- Activates AMPK — the master regulator of cellular energy balance
- Studied for improvements in insulin sensitivity and glucose uptake
- Promotes mitochondrial biogenesis and metabolic flexibility
- Studied for anti-ageing effects via AMPK/FOXO pathway activation
- Reduces oxidative stress and inflammation in metabolic disease models
Mechanism of Action
MOTS-c translocates to the nucleus in response to metabolic stress, activating AMPK and regulating the folate cycle and de novo purine synthesis. This drives metabolic adaptation and improves cellular energy efficiency.
🔬 ≥99% by HPLC | Sterile lyophilised powder | Supplied in clear borosilicate glass vial