KPV

KPV is a tripeptide (Lys-Pro-Val) derived from the C-terminal sequence of α-MSH. It retains the anti-inflammatory properties of the parent peptide while being significantly smaller and more stable.

Key Research Areas

• Potent anti-inflammatory effects via NF-κB pathway inhibition
• Studied for wound healing acceleration in skin and mucosal tissue
• Reduces pro-inflammatory cytokines (IL-6, IL-8, TNF-α) in cell models
• Studied for inflammatory bowel disease (IBD) and colitis models
• Antimicrobial properties studied against Candida and Staphylococcus

Mechanism of Action

KPV inhibits NF-κB nuclear translocation, reducing the transcription of pro-inflammatory genes. It also activates melanocortin receptors (MC1R, MC3R) to produce anti-inflammatory signalling.