AOD-9604

AOD-9604 is a synthetic peptide fragment of human Growth Hormone (hGH), specifically the C-terminal region (amino acids 177–191). It was developed to isolate the lipolytic properties of hGH without its growth-promoting effects.

Key Research Areas

• Stimulates lipolysis (fat breakdown) via β3-adrenergic receptor activation
• Inhibits lipogenesis — reduces new fat cell formation in adipose tissue
• Does not affect IGF-1 levels or promote tissue growth
• Studied for effects on cartilage repair and osteoarthritis models
• Favourable safety profile in preclinical studies — no diabetogenic effects

Mechanism of Action

AOD-9604 mimics the lipolytic domain of hGH, activating β3-adrenergic receptors in adipose tissue to stimulate fat breakdown. Unlike full hGH, it does not bind the GH receptor and does not stimulate IGF-1 production.